Improving the seismic parameters of a structure to enhance the dissipation of earthquake-induced forces is of significant importance in performance-based design. To date, various systems have been developed for resisting lateral forces in structures. The steel plate shear wall is one of the lateral load-resisting systems that possesses the capability for rapid recovery to its original performance, making it suitable for the retrofitting and reuse of structures. In this regard, to enhance the seismic performance and prevent premature and global buckling, the steel plate shear wall system with honeycomb stiffeners was introduced. The high stiffness-to-weight ratio, uniform stress distribution, and energy dissipation capacity are among the important properties of honeycomb lattices. Taking advantage of these benefits, the idea of employing honeycomb stiffeners on both sides of the wall in horizontal and vertical orientations was proposed. The energy dissipation capacity and stiffness, along with high strength at the performance level, were investigated. To this end, 19 numerical models were developed in the Abaqus software and subjected to cyclic loading in accordance with the loading protocol, through which the seismic parameters of this system were evaluated and interpreted. The results showed that the steel plate shear wall with honeycomb stiffeners in the horizontal arrangement exhibited twice the energy dissipation capacity compared to the vertical arrangement. For both stiffener arrangements, increasing the depth and thickness of the stiffeners resulted in an approximate 4% increase in strength. Furthermore, the elastic stiffness of the steel plate shear wall with the vertical arrangement was observed to be higher than that of the horizontal arrangement.