Sustainable development in earthquake engineering necessitates a paradigm shift from traditional ductility-based design philosophies toward innovative structural resilience and seismic recoverability strategies. In this context, the deployment of sacrificial structural fuses as primary energy dissipation elements in steel frames represents an efficient approach to concentrate damage and facilitate repairability. This study presents an experimental and numerical investigation into the cyclic behavior of mechanical auxetic metamaterials with a re-entrant geometric lattice, serving as energy-channelling structural fuses. These fuses were fabricated from 316L stainless steel using additive manufacturing via laser powder bed fusion (L-PBF). Cyclic evaluations demonstrate that these 3D-printed auxetic configurations exhibit a synchronized kinematic response, leading to a balanced and pervasive stress redistribution across the ligament network. Utilizing the negative Poisson's ratio effect to mobilize a larger volume of material within the severe plastic regime, this mechanism achieves an exceptionally high specific energy absorption capacity. Furthermore, a high-fidelity numerical model was developed in ABAQUS to predict ultra-low cycle fatigue (ULCF) life. The model calibration was performed utilizing advanced ductile fracture mechanics criteria and the cyclic void growth model (CVGM), which demonstrated excellent agreement with the experimental results. The findings of this research establish the significant potential of auxetic metamaterials as high-efficiency structural fuses in resilient earthquake engineering.