In this research, the combination of self-control ideas and inter are used to reduce wind-induced vibrations in tall buildings. The self-control idea was implemented by isolating a part of the main structure in its upper part as a dynamic vibration absorber (DVA), and the inerter device was installed between the DVA and the main structure. An example of a tall building is presented and its response was determined using a multi-degrees-of-freedom (MDOF) model with the random vibration method. The response of the uncontrolled state and three controlled conditions including the structure equipped with tuned mass damper (TMD) and the structure with substructure with and without inerter was determined. For the uncontrolled structure, the crosswind acceleration exceeded the occupant comfort level. The TMD played an effective role in reducing the structural vibrations. The acceleration reduction for a mass ratio of 1% was 48%. However, TMD’s use requires adding additional mass to the structure and allocating a valuable part of the building to accommodate the damper and its vibration amplitude. For the self-control system, in the case without inerter, the system performance was a function of the mass ratio of the substructure. For instance, the acceleration reduction for th mass ratio 6%, was 52%. By adding inerter, the vibration amplitude of the structure and substructure was further reduced and the system performance was improved. For example, the acceleration for the substructure with a mass ratio of 6% and the inerter with height and inertance ratios of 10 and 30% reduced by 56%. The proposed system, which simultaneously benefits from the advantages of the self-control system and the inertia device, and has not limitations of TMD, is capable of optimally controlling the vibrations of the structure and meeting the occupants comfort criteria.